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Who We Are
Our Scientists
The logic behind our approach
Our Scientists
We are a team of knowledgeable scientists with 20 plus years of experience in basic preclinical and translational scientific research with focus on chronic metabolic diseases. We have extensive experience in studying endocrine and hormonal regulation of cellular processes, particularly, the molecular action of nutrients on metabolic pathways. Our research employs advanced analytical tools that capitalize on the use of stable isotope tracer labeling methods to tease apart biochemical kinetics and answer clinically relevant questions related to metabolic disease states, this includes direct measures of hormone-mediated signal transduction.
The logic behind our approach
Our Scientists
A core principle at NutrArgan is that complex diseases can be managed by taking a natural approach which hits multiple targets.
The logic behind our approach
The logic behind our approach
The logic behind our approach
The rise in consumption of processed foods high in calories, that exceed metabolic energy demand, especially refined carbohydrates and saturated fat, results in increased plasma levels of fatty acids and sugar (glucose) which are converted into triglycerides. This excess triglyceride can be distributed in fat tissue, liver and muscle and lead to the development of insulin resistance and impairs peripheral glucose disposal. Once started, the problem worsens since a reduction in insulin-mediated control of adipose tissue lipolysis leads to the release of free fatty acids in plasma. If left untreated, these metabolic defects can lead to the development of chronic diseases such as type 2 diabetes, cardiovascular disease, nonalcoholic fatty liver disease (NAFLD) and even cancer.
Metabolic diseases represent complex physiological states, characterized by multiple layers of intertwined biochemical and hormonal dysfunctions which are linked to chronic inflammation and oxidative tissue damage. For example, obesity is associated with insulin resistance and low grade chronic inflammation. The release of inflammatory cytokines such as, TNF-alpha, IL-1beta and IL-6, from fat tissue further exacerbates insulin resistance and impairs homeostatic regulation.
Targeting a single aspect of these defects is somewhat futile. We need disease management strategies that will counteract oxidative stress and inflammation while promoting metabolic health. Natural foods and bioactive plant-derived compounds, which possess health benefits in addition to their basic nutritional value, could provide a multi-targeted approach for managing metabolic diseases.